CJC-1295
A growth hormone releaser that’s almost always paired with ipamorelin. Together they trigger a bigger, cleaner GH pulse than either alone — without the cortisol spike or hunger surge from older GH peptides.
What it does
CJC-1295 is a modified version of your body’s own GHRH (growth hormone-releasing hormone). It tells your pituitary gland to release more GH. It comes in two versions:
Without DAC (also called Mod GRF 1-29): short half-life (~30 min), gives a clean pulsatile GH release. This is the more popular research form — taken 1–3x/day fasted, almost always with ipamorelin.
With DAC (drug affinity complex): half-life of ~7 days, dosed 1–2x/week. More convenient but produces a more sustained, less pulsatile GH elevation.
The CJC-1295 + ipamorelin stack is one of the most used combinations in peptide research. They work on different receptors (GHRH vs. ghrelin) and the effects are additive — producing a stronger, longer GH pulse than either compound alone.
How it works
GHRH receptor agonist
Stimulates the pituitary through GHRH receptors. A completely different pathway than ipamorelin (ghrelin receptors) — which is why the combination is additive.
Sleep-phase amplification
Natural GH peaks during deep sleep. Injecting CJC-1295 no DAC before bed amplifies this nocturnal pulse — the most impactful timing for GH benefits.
IGF-1 elevation
The GH release it triggers leads to higher IGF-1, which drives muscle repair, fat oxidation, and recovery benefits associated with elevated GH.
Ipamorelin synergy
Together they produce a stronger GH pulse than either alone — without the excess cortisol or hunger you get from older GHRP peptides like GHRP-6.
Dosing
| Use / Phase | Dose | Frequency | Notes |
|---|---|---|---|
| No DAC + ipamorelin | 100–300 mcg each | 1–3x daily, fasted | Before bed is the key timing |
| With DAC (solo) | 1–2 mg | 1–2x per week | Less pulsatile, more convenient |
| Cycle length | — | 8–16 weeks | Then 4 weeks off |
The no-DAC version must be taken fasted (no food or insulin-spiking supplements for at least 2 hours). Food significantly blunts the GH response. The DAC version doesn’t have this timing sensitivity.
Reconstitution
Add 2–3 ml of bacteriostatic water to your vial. For the CJC + ipamorelin stack, you can draw both compounds into the same syringe for a single injection.
For exact volumes, use the reconstitution calculator →
Storage
- ❄️Dry powder: Refrigerate at 2–8°C. Stable for 12–18 months.
- 💧After mixing: Refrigerate and use within 4–6 weeks.
- 🌞️Avoid: Direct sunlight and heat. Never freeze the mixed solution.
Where to buy
| Supplier | Size | Price | Coupon |
|---|---|---|---|
| ManaWell Research | 5 mg | ~$32 | PROTOCOL10 Shop → |
| Limitless Life | 5 mg | ~$35 | PEPTI |
| Amino Sequence | 5 mg | ~$30 | PEPTI |
| Polaris Peptides | 5 mg | ~$33 | PEPTI |
| Eternal Peptides | 5 mg | ~$31 | PEPTI |
ManaWell Research is our recommended supplier. Use code PROTOCOL10 for 10% off.